Enhance the throughput and statistical significance of your TMA studies 

The use of Tissue Micro array Analysis (TMA) is now becoming standard practice in research pathology laboratories. Preparation automation allows one to deposit hundreds of tissue cores coming from different individuals or corresponding to different staining on the same slide. This is a powerful technique that enhances throughput and leads to greater statistical significance of the results.

However, the standard manual analysis of the slide with a conventional microscope is a very tedious and time-consuming job, and so in practice the relevance of the method and the timing of the availability of the results is usually limited by a manpower bottleneck. 

Digital slide scanning systems which can produce a virtual slide of a TMA slide used in combination with dedicated TMA analysis software are significantly increasing the throughput of these processes.

Benefits of the virtual slide approach

• Automatically segment the TMA cores
• Automatically store the cores in a database
• Powerful data mining 
• Make cores immediately available to your colleagues and collaborators
• Automatically keeping analysis results linked with their source cores, allowing on-demand validation and reassessment
• Employ automatic analysis software to free up manpower and reduce subjectivity of results
• Easily perform cross-study correlation analysis, even if it requires access to original core source images
• Easy report generation

Tisue Micro Array Observations. Inclusive observations are crried out by arranging a variety of organ tissue sections on a single glass slide

Slide provided by Jumya Fukuoka, Laboratory of Pathology, Toyama University Hospital

Applications

• Cancer research – marker scoring
• Therapeutic target validation
• Toxicology
• Pharmacology testing
• Differential gene expression study
• Fluorescence TMA
• Mouse and rat phenotype studies